Bone Abstracts

Objectives: Osteosarcoma is the most common primary bone cancer and most frequent cause of cancer-related deaths in children and adolescents. Osteosarcoma cells are able to establish a crosstalk with resident bone cells leading to the formation of a deleterious vicious cycle. We hypothesized that osteosarcoma cells can release in the bone microenvironment transforming Extracellular Vesicles (EVs) involved in regulating the bone cell proliferation and differentiation, thereby p...